Low Grade Inflammation and Cardiovascular Disease Risk among First Degree Relatives of Persons with Type 2 Diabetes Mellitus in a Northern Nigerian Population
Low grade or subclinical inflammation has been reported in various literatures as a marker, predictor, or pathogenetic factor in the development of cardiovascular diseases (CVD) and type 2 diabetes mellitus.The risk factors for the development of type 2 diabetes mellitus (DM) have been broadly classified into environmental and genetic factors. First degree relatives (FDR) of persons with type 2 DM (FDRs) are most likely to have inherited genes that will predispose them to diabetes. Does it mean that these FDRs will also have genetic susceptibility to cardiovascular diseases? We aimed to assess low grade inflammation/CVD risk in FDRs and to determine whether FDR status, obesity indices, blood pressure levels, and plasma glucose levels are independent risk factors for low grade inflammation and CVD risk. First degree relatives of persons with type 2 diabetes and controls were recruited from their respective communities after due consent. Relevant biodata were documented and appropriate examinations including anthropometric measurements were carried out. Laboratory investigations (plasma glucose levels and high sensitivity C-reactive protein (hsCRP) were subsequently done. Out of a total of 35.4% of participants that fell under the ‘high’ CVD risk category, FDRs and controls constituted 24.7% and 10.6% respectively. Logistic regression analysis showed that significant independent determinants of low grade inflammation and CVD risk included FDR status, smoking, some obesity indices, and elevated plasma glucose levels.
Copyright (c) 2019 Y Lawal, F Bello, FE Anumah, AG Bakari
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